画钟试验在轻度认知障碍与轻度阿尔茨海默病中的鉴别作用

摘要

目的：探讨画钟试验对轻度认知障碍(MCI)和轻度阿尔茨海默病(AD)的鉴别作用。方法收集2011年10月~2013年10月本院神经内科门诊及住院收治的认知功能障碍患者的临床资料，筛选出MCI患者65例，轻度AD患者63例，比较两组患者间3分法画钟试验评分，应用操作者特征性曲线确定画钟试验对区别MCI及轻度AD的敏感性和特异性。结果两组患者年龄、性别、受教育程度匹配，简易精神状态检查(MMSE)及画钟试验评分有显著性差异(P<0.05)。3分法画钟试验区别MCI与轻度AD的敏感性为54.0%，特异性为80.9%。结论画钟试验对鉴别MCI与轻度AD方面有一定帮助，但仍需与其他认知功能筛查量表联合使用。%Objective To investigate the potential of the Clock Drawing Test (CTD) in differentiating the mild cognitive impairment (MCI) and Alzheimer's disease (AD). Methods Cognitive impaired patients admitted to the outpatient and inpatient of neurological depart-ment of our hospital from October 2011 to October 2013 were reviewed. There were 65 cases with MCI and 63 cases with AD. The scores of CDT were compared between them, and the sensitivity and specificity were evaluated with Receiver Operating Characteristic Curve. Re-sults The MCI group and AD group matched in age, gender and education. The scores of Chinese version of the Mini-Mental State Examina-tion and CDT were significantly defferent between the two groups. The sensitivity of 3-point CDT was 54.0%and the specificity was 80.9%in differentiating MCI and AD. Conclusion CDT is helpful to differentiate MCI from AD only in a set of assessment.