Long-term safety and efficacy study of a medical device containingxyloglucan pea protein reticulated with tannins and xylo-oligosaccharides inpatients with diarrhoea-predominant irritable bowel syndrome

摘要

Irritable bowel syndrome with diarrhoea (IBS-D) is a frequent problemassociated with a significant socioeconomic implication. Increased gutpermeability is an important pathophysiological mechanism. A medical devicecontaining xyloglucan (XG), pea protein and tannins (PPT) from grape-seedextract, and xylo-oligosaccharides (XOS) has proven restoration ofintestinal barrier function. Our objective was to evaluate the efficacy andsafety of treatment with the medical device XG + PPT + XOS (XG-PPT-XOS) inadult patients with IBS-D in a clinical setting for 6 months.