2020 Guidelines of the Polish Society of Laboratory Diagnostics (PSLD) and the Polish Lipid Association (PoLA) on laboratory diagnostics of lipid metabolism disorders

摘要

The lipid profile, which is routinely done to assess a cardiovascular risk, involves the measurement/calculation of serum/plasma levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG) and non-HDL cholesterol (non-HDL-C), although LDL-C measurement still plays a key role in the diagnosis, prediction and the monitoring of both the course and treatment of lipid disorders [ – ]. The results of the measurements indirectly and approximately reflect the blood content of individual lipoproteins. Quantitative measurement of atherogenic lipoproteins, i.e. LDL, lipoprotein(a) [Lp(a)], chylomicron (CM) remnants and very low-density lipoprotein (VLDL) remnants, is of special importance in laboratory assessment of lipid metabolism and the risk of atherosclerosis progression [ , ]. This is why lipid profile, which usually applies only to the LDL level, should be supplemented with the measurement of Lp(a) as well as CM and VLDL remnants, if possible.