Microfluidic single vessel production of hypoxia tracer 1H-1-(3-18F-fluoro-2-hydroxy-propyl)-2-nitro-imidazole (18F-FMISO)

摘要

We report an automated synthesis of [18F]-FMISO utilizing a prototype microfluidic radiochemistry module. The instrument allows for production of the tracer with 58% ± 2% (11 runs) decay corrected yield. Total time of production, including synthesis and purification averages 60 minutes. Use of the microfluidic platform results in a specific activity of 138.6 GBq/μmol, which is higher than previously reported for conventional reactors.