A cytotoxic decahydronaphthalenylpropenal derivative and tetrahydrofuran lignans from the stems of Cameraria latifolia

摘要

A new decahydronaphthalenylpropenal derivative, (+)-camerarialdehyde (>1), a new tetrahydrofuran lignan, (–)-diepiolivil (>2), and two known lignans were isolated from a methanol-soluble extract of the stems of Cameraria latifolia, which was obtained from a repository donated to IHVR by Merck Research Laboratories. The structures of compounds >1 and >2 were determined by interpretation of their spectroscopic data, with the absolute configuration of >1 being established by analysis of its CD spectrum. The absolute configuration of the 1,3-diol moiety of >2 was proposed from the CD spectrum induced with dimolybdenum tetraacetate in DMSO solution. All compounds isolated were evaluated against HT-29 human colon cancer cells, and compound >1 was found to show cytotoxicity toward this cell line.