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Partially Silencing Brain Toll-Like Receptor 4 Prevents in Part Left Ventricular Remodeling with Sympathoinhibition in Rats with Myocardial Infarction-Induced Heart Failure

机译：部分沉默的脑收费类似受体4预防心肌梗塞诱发的心力衰竭大鼠的部分左心室重构与交感神经抑制

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BackgroundLeft ventricular (LV) remodeling and activation of sympathetic nervous system (SNS) are cardinal features of heart failure. We previously demonstrated that enhanced central sympathetic outflow is associated with brain toll-like receptor 4 (TLR4) probably mediated by brain angiotensin II type 1 receptor in mice with myocardial infarction (MI)-induced heart failure. The purpose of the present study was to examine whether silencing brain TLR4 could prevent LV remodeling with sympathoinhibition in MI-induced heart failure.

机译：背景左心室（LV）重塑和交感神经系统（SNS）激活是心力衰竭的主要特征。我们以前证明，在患有心肌梗死（MI）的心力衰竭小鼠中，增强的中枢交感神经流出可能与脑通行费样受体4（TLR4）有关，该受体可能是由脑血管紧张素II 1型受体介导的。本研究的目的是研究沉默脑TLR4是否可以在MI引起的心力衰竭中通过交感神经抑制来阻止LV重塑。

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Kiyohiro Ogawa; Yoshitaka Hirooka; Takuya Kishi; Tomomi Ide; Kenji Sunagawa;
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年(卷),期 -1(8),7
年度 -1
页码 e69053
总页数 7
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1. An angiotensin receptor blocker prevents arrhythmogenic left atrial remodeling in a rat post myocardial infarction induced heart failure model [J] . KimH.-S., NoC.-W., GooS.-H., Journal of Korean medical science . 2013,第5期

机译：血管紧张素受体阻滞剂可防止心肌梗死诱发的心力衰竭模型中的心律失常性左房重构
2. An Angiotensin Receptor Blocker Prevents Arrhythmogenic Left Atrial Remodeling in a Rat Post Myocardial Infarction Induced Heart Failure Model [J] . Kim Hyun-Su, No Chi-Wan, Goo Sang-Ho, Journal of Korean medical science. . 2013,第5期

机译：血管紧张素受体阻滞剂可预防心肌梗死诱发心力衰竭大鼠心律失常性左心房重构
3. Mineralocorticoid receptor antagonist spironolactone improves left ventricular remodeling in patients with congestive heart failure and acute myocardial infarction. [J] . Tsutamoto T 日本薬理学雑誌 . 2004,第2期

机译：盐皮质激素受体拮抗剂螺内酯可改善充血性心力衰竭和急性心肌梗死患者的左心室重构。
4. Transendocardial injection of myocardial matrix hydrogel improves cardiac function and prevents negative left ventricular remodeling in a porcine myocardial infarction model [C] . Jennifer Singelyn, Michael Salvatore, Kendra Bartels, World biomaterials congress . 2012

机译：经心内膜注射心肌基质水凝胶可改善猪心肌梗死模型的心脏功能并防止左心室重构不良
5. Myocardial Energetic Alterations in Post Myocardial Infarction Left Ventricular Remodeling, Hibernating Myocardium and Pacing Induced Congestive Heart Failure and Amelioration with Stem Cell Transplantation [D] . Jameel, Mohammad Nurulqadr. 2011

机译：心肌梗死后左心室重构，冬眠和起搏引起的充血性心力衰竭和干细胞移植改善心肌的能量变化
6. Noncoordinate regulation of alpha-1 adrenoreceptor coupling and reexpression of alpha skeletal actin in myocardial infarction-induced left ventricular failure in rats. [O] . L G Meggs, J Tillotson, H Huang, 1990

机译：α-1肾上腺素受体偶联的非协调性调节和心肌梗死所致大鼠左心衰竭的α骨骼肌肌动蛋白的重新表达。
7. Partially silencing brain toll-like receptor 4 prevents in part left ventricular remodeling with sympathoinhibition in rats with myocardial infarction-induced heart failure. [O] . Kiyohiro Ogawa, Yoshitaka Hirooka, Takuya Kishi, 2013

机译：部分沉默脑toll样受体4在心肌梗塞诱导的心力衰竭大鼠中部分地防止左心室重构伴有交感神经抑制。
8. Heart Failure: Evaluation and Care of Patients with Left-Ventricular Systolic Dysfunction. Clinical Practice Guideline No. 11; Heart Failure: Management of Patients with Left-Ventricular Systolic Dysfunction. Quick Reference Guide for Clinicians No. 11; Living with Heart Disease: Is It Heart Failure. Patient and Family Guide [R] . 1994

机译：心力衰竭：左心室收缩功能障碍患者的评估和护理。临床实践指南第11号;心力衰竭：左心室收缩功能障碍患者的治疗。临床医生快速参考指南第11号;与心脏病共存：是心衰吗？患者和家庭指南

Partially Silencing Brain Toll-Like Receptor 4 Prevents in Part Left Ventricular Remodeling with Sympathoinhibition in Rats with Myocardial Infarction-Induced Heart Failure

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