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Local transgene expression and whole‐body transgenesis to model brain diseases in nonhuman primate

机译:局部转基因表达和全身转基因模拟非人类灵长类动物的脑部疾病

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摘要

Animal model is an essential tool in the life sciences research, notably in understanding the pathogenesis of the diseases and for further therapeutic intervention success. Rodents have been the most frequently used animals to model human disease since the establishment of gene manipulation technique. However, they remain inadequate to fully mimic the pathophysiology of human brain disease, partially due to huge differences between rodents and humans in terms of anatomy, brain function, and social behaviors. Nonhuman primates are more suitable in translational perspective. Thus, genetically modified animals have been generated to investigate neurologic and psychiatric disorders. The classical transgenesis technique is not efficient in that model; so, viral vector‐mediated transgene delivery and the new genome‐editing technologies have been promoted. In this review, we summarize some of the technical progress in the generation of an ad hoc animal model of brain diseases by gene delivery and real transgenic nonhuman primate.
机译:动物模型是生命科学研究中的重要工具,尤其是在了解疾病的发病机理和进一步的治疗干预成功方面。自从建立基因操纵技术以来,啮齿动物一直是模拟人类疾病的最常用动物。但是,它们仍然不足以完全模仿人脑疾病的病理生理,部分是由于啮齿动物和人类之间在解剖学,脑功能和社交行为方面存在巨大差异。非人类的灵长类动物更适合翻译的角度。因此,已经产生了转基因动物以研究神经和精神疾病。经典的转基因技术在该模型中效率不高。因此,病毒载体介导的转基因传递和新的基因组编辑技术得到了推广。在这篇综述中,我们总结了通过基因传递和真正的转基因非人类灵长类动物生成脑疾病的特设动物模型的一些技术进步。

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