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Increased early mortality and morbidity after total hip arthroplasty in patients with socioeconomic disadvantage: a report from the Swedish Hip Arthroplasty Register

机译:社会经济不佳患者全髋关节置换术后的早期死亡率和发病率增加:瑞典髋关节置换术注册的报告

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摘要

Background and purpose — Socioeconomic status is associated with the outcome of major surgery. We investigated the association of socioeconomic status with the risk of early mortality and readmissions after primary total hip arthroplasty (THA).Patients and methods — We obtained information on income, education, immigration, and cohabiting status as well as comorbidities of 166,076 patients who underwent primary THA due to primary osteoarthritis (OA) from the Swedish Hip Arthroplasty Register, the Swedish National Inpatient Register and Statistics Sweden. Multivariable Cox regression models were fitted to estimate the adjusted risk of mortality or readmissions within 90 days after index surgery.Results — Compared with patients on a low income, the adjusted risk of 30-day mortality was considerably lower in patients on a high income (hazard ratio [HR] 0.5, 95% confidence interval [CI] 0.3–0.7) and in those on a medium income (HR 0.7, CI 0.6–0.9). Similar risk reductions were found for the endpoint 90-day mortality. Patients with a high income had a lower adjusted risk of readmission for cardiovascular reasons than those with a low income (HR 0.7, CI 0.6–0.9), as had those with a higher level of education (adjusted HR 0.7, CI 0.6–0.9). Patients with higher socioeconomic status had a lower degree of comorbidities than socioeconomically disadvantaged patients. However, adjusting for socioeconomic confounders in multivariable models only marginally influenced the predictive ability of the models, as expressed by their area under the curve.Interpretation — Income and level of education are strongly associated with early mortality and readmissions after primary THA, and both parameters are closely connected to health status. Since adjustment for socioeconomic confounders only marginally improved the predictive ability of multivariable regression models our findings indicate that comorbidities may under certain circumstances serve as an acceptable proxy measure of socioeconomic background.
机译:背景和目的-社会经济状况与大手术的结果相关。我们调查了原发性全髋关节置换术(THA)后社会经济状况与早期死亡和再次入院风险之间的关系。患者和方法-我们获得了有关收入,教育,移民和同居状况以及共166,076例患者的合并症的信息由于瑞典髋关节置换术注册机构,瑞典国家住院患者注册和统计机构的原发性骨关节炎(OA)而导致的原发性THA。拟合了多变量Cox回归模型,以评估指数手术后90天内死亡率或再次入院的调整后风险。结果—与低收入患者相比,高收入患者30天死亡率的调整后风险要低得多(危险比[HR] 0.5,95%置信区间[CI] 0.3-0.7)和中等收入人群(HR 0.7,CI 0.6-0.9)。对于终点90天死亡率,发现了类似的风险降低。高收入者由于心血管原因而调整后的再次入院风险低于低收入者(HR 0.7,CI 0.6-0.9),受教育程度较高的患者(调整后HR 0.7,CI 0.6-0.9) 。社会经济地位较高的患者合并症的发病率低于社会经济弱势的患者。但是,对多变量模型中的社会经济混杂因素进行调整只能在一定程度上影响模型的预测能力,如曲线下的面积所示。解释—收入和教育水平与原发性THA后的早期死亡率和再入院密切相关,并且这两个参数与健康状况紧密相关。由于对社会经济混杂因素的调整只能稍微改善多元回归模型的预测能力,因此我们的研究结果表明,合并症在某些情况下可以作为社会经济背景的可接受替代指标。

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