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Evaluation of a protocol for selective empiric treatment of feverwithout localising signs

机译:评价选择性经验性发烧治疗方案没有本地化的迹象

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摘要

Accepted 8 November 1996
A protocol for management of young febrile children at risk for bacteraemia has been used at Westmead Hospital, a university based hospital in the western Sydney region, since early 1994.Implementation of the protocol was retrospectively evaluated for the 12 month period 1 June 1994 to 31 May 1995, using the emergency department log book as the primary data source. Altogether 498children, aged from 3 months to 3 years, with a fever ⩾39.50C were identified over this period, of whom 291 were admitted to hospital because of evidence of sepsis or identified focal infection and 207 children without focal infection were observed in the short stay annexe of the emergency department. Fifty children, considered at high risk of bacteraemia because of a total white cell count ⩾20 × 109 / l received empiric antibiotic treatment with ceftriaxone, of whom 19 subsequently had proved bacteraemia and another 10 had focal infection identified during observation in the short stay annexe. Bacteraemia was due to Streptococcus pneumoniae in 16cases andHaemophilus influenzae type b in three. No adverse events occurred at follow up.
Use of a management protocol and selection on higher whitecell count criterion than previously recommended by US centres resultedin restriction of empiric antibiotic treatment to a small proportion ofyoung febrile children presenting to a busy emergency department ofwhom 38% were bacteraemic.

机译:自1994年初起,西悉尼地区一家大学医院Westmead医院就开始使用一项针对具有菌血症风险的高热儿童进行治疗的方案,该方案自1994年初开始进行了回顾性评估。 1994年6月1日至1995年5月31日这12个月期间,以急诊科日志为主要数据源。在此期间,共鉴定出498名年龄在3个月至3岁之间的儿童,发烧⩾39.5 0 C,其中291名因败血症或发现局灶性感染而入院,其中207名儿童在急诊室的短期住宿中未观察到无局灶性感染。 50名因白细胞总数≥20×10 9 / l而被认为具有高菌血症风险的儿童接受了头孢曲松的经验性抗生素治疗,其中19名随后被证明具有菌血症,另外10名患有局部感染在短期停留附件中观察期间发现。细菌血症是由于肺炎链球菌16例和乙型流感嗜血杆菌三分之二。随访时未发生不良事件。
使用管理规程并选择较高的白度细胞计数标准比美国中心先前推荐的结果高限制经验性抗生素治疗的比例很小年幼的发热儿童向繁忙的急诊科就诊其中38%是细菌。

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