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Catheter Ablation for Atrial Fibrillation in Systolic Heart Failure Patients: Stone by Stone a CASTLE

机译:收缩性心力衰竭患者的房颤消融术:一石一石一座城堡

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摘要

Heart failure (HF) and AF frequently coexist and are involved in a vicious cycle of adverse pathophysiologic interactions. Applying treatment algorithms that have been validated in the general AF population to patients with AF and HF may be fraught with risks and lack effectiveness. While firm recommendations on using catheter ablation for AF do exist, the subset of patients also suffering from HF needs to be further evaluated. Observational data indicate that a significant number of ablation procedures are performed in patients with coexistent HF. Initial randomised data on outcomes are encouraging. Apart from sinus rhythm maintenance, benefits have been observed in terms of other significant endpoints, including left ventricular ejection fraction, quality of life, exercise capacity and hospital readmissions for HF. Limited existing data on survival are also promising. In the present article, observational and randomised studies along with current practice guidelines are summarised.
机译:心力衰竭(HF)和AF通常并存,并参与不良病理生理相互作用的恶性循环。将已在一般房颤人群中验证过的治疗算法应用于房颤和心衰患者可能会充满风险且缺乏有效性。尽管确实存在使用导管消融治疗房颤的坚定建议,但也需要进一步评估也患有HF的部分患者。观察数据表明,在并发HF的患者中进行了大量消融手术。关于结果的初步随机数据令人鼓舞。除维持窦性心律外,在其他重要终点方面还观察到了益处,包括左心室射血分数,生活质量,运动能力和心衰住院率。现有的有限的生存数据也很有希望。在本文中,对观察性研究和随机研究以及当前的实践指南进行了总结。

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