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Validated determination method of tramadol and its desmethylates in human plasma using an isocratic LC-MS/MS and its clinical application to patients with cancer pain or non-cancer pain

机译：等度LC-MS / MS验证的血浆中曲马多及其去甲基化物的验证方法及其在癌性疼痛或非癌性疼痛患者中的临床应用

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摘要

BackgroundThis study aimed to develop a simultaneous determination method for tramadol and its desmethylates in human plasma using isocratic liquid chromatography coupled to tandem mass spectrometry and to validate it for pharmacokinetic evaluation in patients with cancer pain or non-cancer pain.

机译：背景本研究旨在开发一种使用等度液相色谱-串联质谱联用同时测定人血浆中曲马多及其去甲基化物的方法，并验证其可用于癌症疼痛或非癌性疼痛患者的药代动力学评估。

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期刊名称 Journal of Pharmaceutical Health Care and Sciences
作者
Hironari Tanaka; Takafumi Naito; Yasuaki Mino; Junichi Kawakami;
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作者单位

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年(卷),期 2016(2),-1
年度 2016
页码 25
总页数 9
原文格式 PDF
正文语种
中图分类药学;
关键词
Tramadol Desmethylate LC-MS/MS Human plasma Pharmacokinetics;

机译：曲马多;去甲基酯;LC-MS / MS;人血浆;药代动力学;

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专利

1. Validated determination method of tramadol and its desmethylates in human plasma using an isocratic LC-MS/MS and its clinical application to patients with cancer pain or non-cancer pain [J] . Hironari Tanaka, Takafumi Naito, Yasuaki Mino, Journal of Pharmaceutical Health Care and Sciences . 2016,第1期

机译：等度LC-MS / MS验证的血浆中曲马多及其去甲基化物的验证方法及其在癌性疼痛或非癌性疼痛患者中的临床应用
2. Development and validation of a sensitive LC-MS/MS method for determination of gefitinib and its major metabolites in human plasma and its application in non-small cell lung cancer patients [J] . Guan Shaoxing, Chen Xi, Wang Fei, Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis . 2019,第期

机译：敏感LC-MS / MS法测定吉非替尼的敏感LC-MS / MS方法及其在人血浆中的主要代谢产物及其在非小细胞肺癌患者中的应用
3. Systematic evaluation of matrix effect and cross-talk-free method for simultaneous determination of zolmitriptan and N-desmethyl zolmitriptan in human plasma: a sensitive LC-MS/MS method validation and its application to a clinical pharmacokinetic study [J] . Patel Bhargav, Suhagia B. N., Jangid Arvind G., Biomedical Chromatography: An International Journal Devoted to Research in Chromatographic Methodologies and Their Applications in the Biosciences . 2016,第3期

机译：同时测定人血浆中佐米曲普坦和N-去甲基佐米曲普坦的基质效应和无串扰方法的系统评价：灵敏的LC-MS / MS方法验证及其在临床药代动力学研究中的应用
4. Validated LC-MS/MS method for the determination of enantiomeric purity of S-Amlodipine in human plasma: Application to pharmacokinetic study. [C] . Soowan Choi, Youngho Park, Kyungtae Lee International Mass Spectrometry Conference . 2014

机译：验证的LC-MS / MS法测定人血浆中S-氨基氨基的对映体纯度的方法：对药代动力学研究的应用。
5. The influence of pain self-management education on the prevalence of opioid prescription among patients with chronic non-cancer pain: An agent-based modeling simulation. [D] . Samuel-Ojo, Catherine O. 2015

机译：疼痛自我管理教育对慢性非癌性疼痛患者中阿片类药物处方的影响：基于代理的建模仿真。
6. Development and validation of a bioanalytical method to quantitate enzalutamide and its active metabolite N-desmethylenzalutamide in human plasma: application to clinical management of metastatic castration-resistant prostate cancer patients [O] . Guillemette E Benoist, Eric van der Meulen, Inge M van Oort, -1

机译：定量测定人血浆中enzalutamide及其活性代谢物N-desmethylenzalutamide的生物分析方法的开发和验证：在转移性去势抵抗性前列腺癌患者的临床管理中的应用
7. Validated determination method of tramadol and its desmethylates in human plasma using an isocratic LC-MS/MS and its clinical application to patients with cancer pain or non-cancer pain [O] . 2016

机译：等度LC-MS / MS验证的血浆中曲马多及其去甲基化物的验证方法及其在癌性疼痛或非癌性疼痛患者中的临床应用

Validated determination method of tramadol and its desmethylates in human plasma using an isocratic LC-MS/MS and its clinical application to patients with cancer pain or non-cancer pain

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