A new nortriterpenoid, 19(R)-hydroxyl-wuweizidilactone H (>1), and a sesquiterpene, (6R)-β-chamigrenic acid (>2), together with one known nortriterpenoid, wuweizidilactone H (>3), and three known hepatoprotective lignans, micrantherin A (>4), gomisin M2 (>5) and schizandrin (>6) were isolated from the fruit of Schisandra chinensis. Their structures were elucidated by UV, IR, HRESIMS, NMR spectra and X-ray analysis. Among them, the absolute configuration of >2 was confirmed for the first time. In vitro assays, compounds >4–>6 (10 μM) exhibited hepatoprotective activities (survival rate: 44%, 43% and 44%) against damage induced by N-acetyl-p-aminophenol (APAP) in human liver carcinoma (HepG2) cells.
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