Evidence of improving survival of patients with rectal cancer inFrance: a population based study

摘要

BACKGROUND—Over the past 20 years there have been many changes in the management of rectal cancer. Their impact on the overall population is not well known.
AIMS—To determine trends in management and prognosis of rectal cancer in two French regions.
SUBJECTS—1978 patients with a rectal carcinoma diagnosed between 1978 and 1993.
METHODS—Time trends in treatment, stage at diagnosis, operative mortality, and survival were studied on a four year basis. A non-conditional logistic regression was performed to obtain an odds ratio for each period adjusted for the other variables. To estimate the independent effect of the period a multivariate relative survival analysis was performed.
RESULTS—Over the 16 year period resection rates increased from 66.0% to 80.1%; the increase was particularly noticeable for sphincter saving procedures (+30.6% per four years, p=0.03). The percentage of patients receiving adjuvant radiotherapy increased from 24.0% to 40.0% (p=0.02). The proportion of patients with Dukes' type A cancer increased from 17.7% to 30.6% with a corresponding decrease in those with more advanced disease. Operative mortality decreased by 31.1% per four years (p=0.03). Allthese improvements have resulted in a dramatic increase in relativesurvival (from 35.4% for the 1978-1981 period to 57.0% for the1985-1989 period).
CONCLUSIONS—Substantial advances inthe management of rectal cancer have been achieved, but there isevidence that further improvements can be made in order to increase survival.

Keywords:rectal cancer; treatment; stage at diagnosis; survival; time trends; cancer registries