目的：从生物力学角度探讨Ⅰ型牛胶原蛋白生物膜预防肌腱粘连作用。方法：三黄鸡，3月龄，60只，雌雄各半，体重1.5～2.0 kg，以右足第3趾屈趾深肌腱断裂1/2吻合模型，随机分为假手术组、对照组和Ⅰ型牛胶原蛋白生物膜组，再根据取材时间分为2周组、4周组、6周组、8周组4个亚组，术后2、4、6、8周对吻合端周围粘连程度观察和对包括患侧及健侧第3趾关节屈曲角度、肌腱滑动距离、肌腱最大抗断裂负荷的生物力学检测。结果：Ⅰ型牛胶原蛋白生物膜在术后2、4、6、8周，与假手术组及对照组比较，粘连程度评分明显优于假手术组及对照组（P＜0.05）；生物力学指标测定显示，关节屈曲角度、肌腱滑动距离、肌腱最大抗断裂负荷各项指标，实验组均优于对照组（P＜0.05）。结论：Ⅰ型牛胶原蛋白生物膜可以减少粘连，提高肌腱生物力学指标，具有一定的预防粘连的作用，是一种有效的预防肌腱粘连的新型生物性材料。%Objective:To explore the preventive effect of type Ⅰbovine collagen membrane on tendon adhesion from the prospective of biomechanics.Methods:Sixty chickens at the age of 3 months, half male and half female, weighing 1.5 to 2.0 kg, were made into models with 1/2 deep tendon rupture on the third toe of the right foot .They were randomly divided into sham group , control group and type Ⅰbovine collagen membrane group .Then four subgroups were divided according to time , including 2 w group, 4 w group, 6 w group, 8 w group.The degree of anastomosis adhesion , the toe joint angle, sliding tendons buckling distance , and tendon rupture of the biggest load were detected .Results:Two, four, six, and eight weeks after the surgery , type Ⅰ bovine collagen membrane group had better results in adhesion score compared with control group (P<0.05);the degree of anastomosis adhesion , the toe joint angle, sliding tendons buckling distance , and tendon rupture of the biggest load were better in the treatment groups (P<0.05).Conclusion:TypeⅠbovine collagen membrane can reduce adhesion , improve the tendon biomechanics index , and has a certain preventive adhesion effect , which is a kind of new biological material to effectively prevent tendon adhesion .
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