白头翁总皂苷-羟丙基-β-环糊精包合物微丸生物利用度研究

摘要

目的：研究白头翁总皂苷-羟丙基-β-环糊精包合物微丸的生物利用度。方法：分别单剂量口服给药白头翁总皂苷和白头翁总皂苷-羟丙基-β-环糊精包合物微丸（200 mg／kg），采用 LC-MS 法测定大鼠血药浓度，根据大鼠体内血药浓度经时过程，计算相应的药代动力学参数。结果：白头翁总皂苷和白头翁总皂苷-羟丙基-β-环糊精包合物微丸 AUC 分别为574.82和1776.32μg／（L·h）。结论：白头翁总皂苷制成羟丙基-β-环糊精包合物微丸后生物利用度显著提高。%Objective:To explore the bioavailability of Pulsatilla total saponins-hydroxypropyl -β-cyclodextrin clathrate pellets. Methods:The total Saponin of Pulsatilla Chinensis Regel and its OH-β-CD clathrate Pellets (200 mg/kg)were administered in rats respectively,the plasma levels were determined by LC-MS.Then the corresponding pharmacokinetic parameters based on the time process of blood drug concentration were calculated.Results:AUC of the Total Saponin of Pulsatilla Chinensis Regel and its OH-β-CD inclusion complex were 574.82 and 1776.32μg/L·h.Conclusion:The bioavailability of pulsatilla total saponins can be improved significantly by the technology of hydroxypropyl-β-cyclodextrin inclusion.