目的：探讨银丹脑血通辅助治疗急性脑梗死患者的疗效，以及对血清 hs-CRP、TNF-α和 IL-6等炎性反应因子的影响。方法：随机选取2015年7月至2016年7月收治的70例急性脑梗死患者，采用随机数字表法分为研究组与对照组各35例。2组患者均给予常规基础治疗，并给予阿司匹林肠溶片口服，100 mg／次，1次／d；吡拉西坦口服，0．8 g／次，3次／d；以及依达拉奉注射液进行静脉滴注，30 mg／次，2次／d。其中，研究组在上述治疗方案的基础上，联用银丹心脑通软胶囊口服，3粒／次，3次／d。2组患者均治疗2周。对2组患者治疗前、治疗1周和2周时，进行血清 hs-CRP、TNF-α和 IL-6的水平检测，并评估其 MESS 评分和 Barthel 指数评分，进行组间疗效对比。结果：1）2组治疗1、2周的 Barthel 指数和 MESS 评分均有显著改善（P ＜0．05）；但研究组的改善均明显优于对照组（P ＜0．05）。2）2组治疗1、2周时的血清 hs-CRP、TNF-α和 IL-6水平均有显著下降（P ＜0．05）；但研究组的3项指标均明显低于对照组（P ＜0．05）。3）研究组在治疗1周时的总有效率为68．6％，治疗2周时为85．7％，均显著高于对照组的54．3％和74．3％（P ＜0．05）。2组患者治疗期间，均未发生严重的不良药物事件。结论：银丹心脑通软胶囊对急性脑梗死患者的炎性损伤有一定的抑制作用，可有效改善患者的神经功能缺损症状，提高其日常生活活动能力。%Objective:To investigate the efficacy of the treatment in patients with acute cerebral infarction with Yindanxinnaootong capsule,and the influence on serum hs-CRP,TNF-αand IL-6.Methods:Totally 70 cases of acute cerebral infarction were ran-domly collected from July-2016 to July 2015,and were randomly divided into a study group and a control group with 35 cases in each.Two groups of patients were given conventional treatment,and also Aspirin Enteric-coated Tablets orally,100 mg each time, once per day;piracetam orally,0.8 g each time,3 times per day;edaravone injection,30 mg each time,twice per day.Besides, the study group was combined with Yindanxinnaotong capsule,oral administration,3 tablets,3 times per day.Two groups of pa-tients were treated for 2 weeks.The serum levels of hs-CRP,TNF-αand IL-6 were detected in two groups before treatment,after 1 week of treatment and 2 weeks,and the MESS score and Barthel index score were evaluated.Results:1)The Barthel index and MESS score of the two groups were significantly improved (P <0.05),but the improvement of the study group was significantly better than that of the control group.2)The serum levels of hs-CRP,TNF-αand IL-6 were significantly decreased (P <0.05)in 1 and 2 weeks of treatment,but the 3 indexes in the study group were significantly lower than those of the control group (P <0.05).3)The total effective rate of the study group at 1 week was 68.6% and 85.7% at 2 weeks,which was both significantly higher than that of the control group (54.3% and 74.3%)(P <0.05).There were no serious adverse drug events in the two groups during the treatment.Conclusion:Yindanxinnaotong capsule inhibits the inflammatory injury of acute cerebral infarction, and can effectively improve the patient′s neurological symptoms and function of pursuing daily activity.
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