Effects of Subacute Pretreatment with Physostigmine Together with Acute AdjunctPretreatment against Soman

摘要

Behavioral observation studies were done to compare the pretreatment benefits ofsubacute and acute delivery of physostigmine salicylate (Phy) against 2 or 5 LD50s of soman in guinea pigs. In a second group of observation studies, the effectiveness of subacute carbamate (Phy or pyridostigmine (Pyr)) in conjunction with acute adjunct (scopolamine or trihexphenidyl) pretreatment was tested against soman (5 LD50), and VX (2 LD50) induced lethality and physical incapacitation in guinea pigs. For all studies, endpoints measured were lethality, % convulsing, degree of incapacitation and recovery time. Subacutely dosed animals were challenged after 7 days of sustained carbamate dosing via 14-day osmotic minipump (Alza 2ML2; OMP). Keywords: Pretreatment, Physostigmine, Subacute, Acute, Osmotic minipump, Scopolamine, Guinea pigs, Soman, Behavioral effects. (js)