玉液汤对糖尿病性黄斑水肿的疗效观察及机制探讨

摘要

Objective:In the present study ,we aimed to to observe the clinical curative effect of Yuye tang in the therapy of diabet -ic macular edema(DME)and investigate the relationship between this effect and IL-6 and VEGF.Methods:A total of 56 patients DME were randomly divided into into 2 groups,28 patients in treatment group were treated with modified Yuye Tang and laser pho-tocoagulation of macular ,28 patients in control group were treated with only laser photocoagulation of macular .Observe visual acui-ty,retinal macular thickness and ocular hemodynamic situation of the two groups after treatment of 4 weeks.The expression of IL-6 and VEGF was assessed by ELISA .Results:Significant differences were observed in terms of intraocular pressure ,visual acuity ,ret-inal macular thickness and ocular hemodynamic situation (P<0.05).Compared with the control group,the expression of IL-6 and VEGF level in the treatment group were significantly decreased (P<0.05).Conclusion:Yuye Tang in the treatment of DME can effectively control the improve eyesight ,retinal macular thickness and ocular hemodynamic situation ,is a kind of safe and effective treatment,worthy of clinical popularization and application ,adjust the IL-6 and VEGF may be Yuye Tang give play to the important targets of therapy effect .%目的：观察玉液汤对糖尿病性黄斑水肿的临床疗效及其与IL-6、VEGF的影响。方法：将60例糖尿病性黄斑水肿患者随机分成2组，治疗组给予玉液汤＋激光光凝治疗，对照组予激光光凝治疗，观察治疗4周后2组视力、视网膜厚度、视网膜血管情况等；应用ELISA检测2组患者血清中IL-6、VEGF含量表达情况。结果：2组经不同方法治疗4周后视力、视网膜厚度、视网膜血管情况比较差异有统计学意义（P＜0.05），治疗组经玉液汤口服治疗与对照组比较，IL-6、VEGF的血清含量情况明显低于对照组，差异有统计学意义（ P＜0.05）。结论：玉液汤治疗糖尿病性黄斑水肿可以有效提高视力、改善视网膜厚度、视网膜血管情况，是一种安全有效的治疗方式，值得临床推广应用，而调节IL-6和VEGF可能是玉液汤发挥治疗作用的重要靶点。