益气养阴法联合TACE治疗中晚期肝癌患者的疗效观察

摘要

目的:探讨益气养阴法联合肝动脉化疗栓塞术(TACE)治疗中晚期肝癌患者的临床疗效.方法:选取2013年3月至2016年3月在河北北方学院附属第一医院介入科收治的中晚期肝癌患者92例.按照随机表法,将患者随机分为观察组和对照组,每组46例.对照组给予TACE治疗,观察组在对照组的基础上联合益气养阴法.治疗两周后,观察2组患者临床疗效、生命质量、肝功能指标和血常规以及不良反应的发生率.结果:观察组有效率(89.13%)明显大于对照组有效率(76.09%)(P＜0.05);观察组治疗前与对照组治疗前患者TBil、AST、ALT、RBC、WBC、PLT比较,差异无统计学意义(P＞0.05);2组治疗前与治疗后患者TBil、AST、ALT、RBC、WBC、PLT比较均有改善作用(P＜0.05);观察组在改善患者TBil、AST、ALT、RBC、WBC、PLT方面均优对照组(P＜0.05);观察组生命质量的改善情况明显优于对照组(P＜0.05);观察组不良反应的发生率明显优于对照组(P＜0.05).结论:益气养阴法联合TACE治疗中晚期肝癌患者能明显改善患者临床疗效、肝功能以及生命质量,而在不良反应发生率方面优于单纯TACE,值得临床推广.%Objective:To investigate the clinical effect of the treatment of middle and late stage hepatocellular carcinoma by the method of replenishing qi and nourishing yin combined with hepatic artery chemoembolization (TACE).Methods:A total of 92 ca－ses of middle and advanced stage hepatocellular carcinoma treated in the Department of Intervention of the First Hospital Affiliated with Hebei Northern University from March 2013 to March 2016 were selected.The patients were randomly divided into observation group (n＝46) and control group (n＝46) according to random table method.The control group was treated with TACE ,and the observation group was treated combined with the method of replenishing qi and nourishing yin .After two weeks of treatment ,the clinical curative effect ,quality of life,liver function index,blood routine and the incidence of adverse reactions were observed.Re－sults:The efficiency of observation group (89.13%) was significantly higher than that of control group (76.09%) (P＜0.05). There was no significant difference between the observation group and the control group in TBil ,AST,ALT,RBC,WBC and PLT (P＞0.05).TBil,AST,ALT,RBC,WBC and PLT of the two groups were improved after treatment (P＜0.05).The observation group was superior to the control group (P＜0.05) in the improvement of Ttil ,AST,ALT,RBC,WBC and PLT.The improvement of qual－ity of life in the observation group was significantly better than that in the control group (P＜0.05).The incidence of adverse reac－tions in the observed group was significantly better than that in the control group (P＜0.05).Conclusion:Replenishing qi and nourishing yin method combined with TACE in treating patients with middle－and advanced stage hepatocellular carcinoma can sig－nificantly improve the clinical efficacy ,liver function and quality of life ,and the incidence of adverse reactions is better than that of simple TACE,which is worthy of clinical promotion.