Analysis on the compatibility rules and mechanism of formulae treatment for COVID-2019 based on the TCM inheritance assistance system and network pharmacology

摘要

cqvip:Background:On December 8,2019,Wuhan City,Hubei Province,a new type of coronavirus disease 2019(COVID-2019)was firstly discovered,and COVID-2019 spread rapidly in China.The number of confirmed cases in various provinces and cities rose sharply in China.In clinical treatment,Chinese medicine treatment showed significant efficacy.Since the outbreak,the National Health Commission(NHS)of China has issued seven editions of the“Pneumonitis Diagnosis and Treatment Program for COVID-2019”,at the same time,most provincial health boards and the Chinese Medicine Administration had also released information on the prevention and control scheme of COVID-2019 by Chinese medicine.The purpose of this study is to explore the compatibility rules of the main drugs in the prescription and the potential mechanism on COVID-2019 pneumonia,in order to provide reference for clinical research and new drug development of COVID-2019.Methods:This article uses the TCM inheritance assistance system and network pharmacology BATMAN-TCM online analysis system to collect and summarize the national“Pneumonitis Diagnosis and Treatment Program for COVID-2019(trial version sixth)”and formulae for adult treatment from the TCM prevention program of 23 provinces and cities.Results:We found that the most formulae for the treatment of COVID-2019 were modified on the basis of Maxing Shigan decoction and the top 5 high-frequencyn drugs are Xingren(Armeniacae semen amarum),Mahuang(Ephedrae herba),Gancao(Glycyrrhizae radix et rhizoma),Shigao(Gypsum fibrosum),and Haungqin(Radix scutellariae).High frequency traditional Chinese medicines are mainly used for relieving the symptoms,clearing away heat,eliminating dampness,resolving phlegm,relieving cough and asthma,promoting water and dampness,and tonifying deficiency.Warm medicine and bitter medicine are the most frequently used drugs in four Qi attribute and five flavor attribute,respectively.Most of drugs are belong to lung,stomach and spleen channel.Mahuang(Ephedrae herba),Xingren(Armeniacae semen amarum),Gancao(Glycyrrhizae radix et rhizoma),Shigao(Gypsum fibrosum),Cangzhu(Atractylodis rhizama)and Huoxiang(Pogostemonis herba)are the core drugs for treating COVID-2019.The TTD disease enrichment,target and signal transduction pathways of the six drugs showed that pneumonia and asthma were most closely related to COVID-2019.And the inflammatory reaction-related pathways may be the main pathways through which these drugs function.Conclusions:The modified Maxing Shigan decoction is the main prescription for the treatment of COVID-2019.The Xingren(Armeniacae semen amarum),Gancao(Glycyrrhizae radix et rhizoma),Shigao(Gypsum fibrosum),Cangzhu(Atractylodis rhizama)and Huoxiang(Pogostemonis herba)have certain theoretical and experimental basis for the treatment of COVID-2019 through network pharmacology analysis,but further experiments are needed to verify the effects.