改良电痉挛治疗对精神分裂症患者血清细胞因子及C-反应蛋白水平的影响

摘要

Objective To explore the effects on cytokines and C - reactive protein after MECT. Methods There are 58 schizo-phrenic patients in the MECT group,41 schizophrenia patients in the drug treatment group,and 82 healthy people in healthy control group. To observe the cytokines(IL - 1,IL - 4,IL - 6,IL - 10)and C - reactive protein before and after the tr eatment. Using PANSS scale to assessment the symptoms. Results ①The malesˊ CRP after the fourth MECT was significantly higher than the females(P <0. 05). ②The MECT groupˊCRP after fourth and sixth treatment were significantly higher than the healthy control group(P < 0. 05),the drug group showed significantly higher CRP after two weeksˊtherapy than the healthy control group(P < 0. 05). ③The IL - 1,IL - 4, IL - 6,IL - 10 of MECT group were not significantly changed before and after treatment ,while the CRP after fourth treatment was sig-nificantly higher than other time points(P < 0. 05). ④The MECT groupˊs total effective rate was 63. 8% ,and the drug groupˊs was 24. 4% ,the difference was statistically significant(P < 0. 01). Conclusion MECT might not cause significant changes in cytokines, but cause CRPˊs stressed elevate,and the males were more sensitive than females.%目的：探讨改良电痉挛治疗（MECT）对精神分裂症患者血清细胞因子及 C -反应蛋白水平的影响。方法选取符合《国际疾病分类（第10版）》（ICD -10）中精神分裂症诊断标准的58名精神分裂症患者为 MECT 组进行 MECT 治疗，41名未行 MECT 的患者为药物组，另选取健康人82名为对照组，三组间性别、年龄均相匹配。观察治疗前后血清白介素-1（Interleukin -1，IL -1）、白介素-4（Interleukin -4，IL -4）、白介素-6（Interleukin -6，IL-6）、白介素-10（Interleukin -10，IL -10）和 C -反应蛋白（C - reactive protein，CRP）水平变化，采用 PANSS 量表测评精神症状。结果①MECT 治疗4次后男性血清 CRP 浓度高于女性，差异有统计学意义（P <0.05）；②MECT组治疗4次后、6次后血清 CRP 浓度高于健康对照组，药物组治疗2周后血清 CRP 浓度高于健康对照组，差异均有统计学意义（P <0.05）；③MECT 治疗前后血清 IL -1、IL -4、IL -6、IL -10浓度差异无统计学意义（P ﹥0.05）， MECT 治疗4次后血清 CRP 浓度高于其他治疗时间点（P <0.05）；④MECT 组有效率为63.8%，药物组为24.4%，差异有统计学意义（P <0.01）。结论 MECT 可能不引起细胞因子的显著变化，但会引起 C -反应蛋白的应激性增高，且男性较女性更为敏感。