Methods of treatment or prevention, in a patient, of anxiety, of a convulsive state, of spasticity or acute muscle spasms, of an affective disorder of an aggressive behavior, of addiction of drugs or alcohol, of abnormal levels of hormone in the plasma, of sleep disorder, a disease or condition or symptom thereof, in a patient affected by the modulation of one or more of the central or peripheral benzodiazepine receptors, pharmaceutical composition, individual dosage form of n-demethylzopiclone, methods for preparing n-demethylzopiclone , and racemic, to prepare (+), and (-) n-desmethyl zopiclone, and, to increase the optical purity of zopiclone or desmethylzopiclone

摘要

"METHODS OF TREATMENT OR PREVENTION, IN A PATIENT, OF ANXIETY, OF A CONVULSIVE STATE, OF SPASTICITY OR ACUTE MUSCULAR SPASMS, OF AN AFFECTIVE DISTURBANCE, OF A BEHAVIORAL DISTURBANCE, OF A DISTURBISHMENT OF A DISTURBISHMENT, A DISTURBISHMENT OF DISTURBING, OR ALCOHOL, ABNORMAL PLASMA HORMONE LEVELS, SLEEP DISTURBANCE, SAME DISEASE OR CONDITION OR SYMPTOM, IN A PATIENT AFFECTED BY MODULATING ONE OR MORE OF THE CENTRAL OR PERIPHERAL BENZODIAZEPINE, PERIPHERAL, PERIPHERAL, PERIPHERAL PERIPHERAL BENEFITS. INDIVIDUAL N-DESMETILZOPICLONA, METHODS TO PREPARE NDESMETHYLZOPYCLONONE, AND RACEMIC, TO PREPARE (+), AND (-) N-DEMETHYLZOPYCLONE, AND TO INCREASE THE OPTICAL PURITY OF ZOPICLONE OR DEMETHYL. The invention is directed to compositions comprising, and methods of using, racemic N-demethylzopiclone, optically pure (+) N-desmethylzopiclone, and (-) optically pure N-desmethylzopiclone, in the treatment and prevention of diseases and conditions in mammals. The invention is further directed to new methods of preparing N-demethylzopiclone, (+) optically pure Ndesmethylzopiclone, and (-) optically pure N-desmethylzopiclone.