术前应用非那雄胺对经尿道前列腺电切术手术效果的影响

摘要

目的 探讨接受经尿道前列腺电切手术(TURP)前应用非那雄胺对降低良性前列腺增生患者经尿道电切综合征(TURS)效果及其作用机制.方法 将接受TURP的良性前列腺增生患者180例随机分成两组,治疗组术前服用非那雄胺,对照组不服用药物.对比两组术中失血情况、术中血钠值,术后免疫组化法检测前列腺组织中血管内皮生长因子(VEGF)表达情况.结果 治疗组术中失血量、前列腺组织中VEGF计数低于对照组(P＜0.05),术中血钠值高于对照组(P＜0.05).结论 术前服用非那雄胺能够防止和减少TURS的发生.%Objective To investigate the effect of application of finasteride before transurethral resection of prostate (TURP) on reducing transurethral resection syndrome (TURS) of patients with benign prostatic hyperplasia.Methods A total of 180 cases of patients with benign prostatic hyperplasia who underwent TURP were randomly divided into two groups:the treatment group who took finasteride before surgery and the control group who did not take medicine.Blood loss and blood sodium levels were compared between the two groups during the operation,and the postoperative expression of vascular endothelial growth factor (VEGF) in prostate tissue was detected by immunohistochemical method.Results The blood loss and VEGF counts in prostate tissue in the treatment group were lower than those in the control group (P ＜ 0.05),but serum sodium was higher than that in the control group (P ＜ 0.05).Conclusion Preoperative application of finasteride can prevent and reduce the occurrence of TURS.