5-羟色胺6受体基因多态性与阿尔茨海默病发病关系的Meta分析

摘要

Objective To explore the relationship between 5-hydroxytryptamine 6 receptor (5-HT6R) C267T gene polymorphism and pathogenesis of Alzheimer's disease ( AD) .Methods We drew up the search strategies , and collected the related literatures on the relationship between gene polymorphism of 5-HT6R C267T and the pathogenesis of AD .Meta analysis was performed with RevMan5.2 software.Hierarchical analysis on the selected Chinese literature which had apoli-poprotein E (ApoE) gene ε4 was conducted, and the publication bias was analyzed by funnel plot .Results Eight inde-pendent case-control studies had been put into this meta-analysis with a total number of 1 969 subjects , comprised of 1 109 patients and 860 controls .There were no associations between 5-HT6 receptor gene polymorphism and pathogenesis of AD in the selected subjects (all P>0.05);in Chinese AD patients′5-HT6 receptor gene C267T without ApoEε4, the C/C, C/T genotypes had relationship with pathogenesis of AD (OR=0.69, 1.63, 95%CI:0.49-0.99, 1.14-2.33; all P<0.05).Conclusion 5-HT6 receptor C267T gene polymorphism is not associated with the pathogenesis of AD , but the C/C and C/T genotypes have relationships with the pathogenesis of AD in Chinese patients without ApoE ε4.%目的：探讨含有或不含有载脂蛋白E（APOE）ε4型的人群5-羟色胺6受体（5-HT6R）基因C267T多态性与阿尔茨海默病（AD）发病的关系。方法制订检索策略，收集5-HT6R基因C267T多态性与AD发病关系的相关文献，采用RevMan5．2软件行Meta分析，对纳入文献按是否含载脂蛋白E（ ApoE）基因ε4型进行分层分析，并通过漏斗图对发表偏倚进行分析。结果共8篇文献纳入研究，纳入人群共1969人，其中病例组1109例，对照组860例。纳入文献总体5-HT6R基因多态性与AD发病无关（P均＞0．05）；在中国人群中，不含ApoEε4型的AD患者5-HT6R基因C267T C／C基因型、C／T基因型与AD发病有关（ OR分别为0．69、1．63，95％CI分别为0．49～0．99、1．14～2．33，P均＜0．05）。结论5-HT6R基因C267T多态性与AD发病无关，但C／C基因型、C／T基因型与不含ApoEε4型的中国人群AD发病有关。