质子泵抑制剂与胃底腺息肉发病关系的研究进展

摘要

Proton pump inhibitor (PPI) is the main drug in the treatment of digestive tract diseases, such as gastrointestinal ulcer, gastroesophageal reflux disease and gastritis. The large amount and long-term use of PPI has caused adverse reactions (such as nutrient deficiencies, osteoporosis, respiratory and intestinal infections, fundic gland polyps, etc.) which are paid much attention to and are also controversial. This paper reviews the research progress in the relationship between proton pump inhibitors and the pathogenesis of fundic gland polyps.%质子泵抑制剂 (Proton pump inhibitor, PPI) 为治疗消化道溃疡、胃食管反流病和胃炎等消化道系统疾病的主要药物.PPI 的大量和长期应用所导致的不良反应 (如营养素缺乏、骨质疏松症、呼吸道和肠道感染、胃底腺息肉等) 也备受关注, 且颇具争议.本文就质子泵抑制剂与胃底腺息肉发病关系的研究进展进行综述.