以降钙素原指导急诊科发热患者抗菌药物使用的临床研究

摘要

目的：探讨降钙素原（ PCT）在急诊科发热患者中指导抗菌药物使用的临床意义。方法纳入四川省人民医院急诊内科以“发热”为主诉收入院患者67例，按照随机数字表法分为PCT指导治疗组（ P组）和常规检查指导治疗组（ C组），比较两组患者的抗菌药物治疗时间、费用、累积DDD数、临床治愈率，记录PCT值随抗菌药物使用的变化。结果 P组患者的抗菌药物使用率、使用时间、抗菌药物治疗费用、累积DDD数、住院时间均低于C组，差异有统计学意义（ P＜0．05），两组临床治愈率比较差异无统计学意义。随着抗菌药物使用，PCT值呈逐步下降趋势。结论检测及动态监测PCT值对临床指导抗菌药物的使用及判断患者感染病情变化具有重要临床意义。%Objective To investigate procalcitonin ( PCT) to guide the clinical significance of the use of antibiotics in emer-gency department patients with fever .Methods 67 cases with fever of unknown origin in the emergency internal medicine were divided into PCT guidance treatment group (group P) and conventional laboratory tests guidance treatment group (group C) randomly.Compare with the time of use antibiotics ,cost,cumulative DDD numbers and clinical cure rate between two groups ,recording the change of PCT along the use of antibiotics .Results Antimicrobial treatment cost ,cumulative DDD numbers ,the usage rate of antibiotics ,and hospital stays in group P were lower than that in group C ,but o in the clinical cure rate showed no statistical significance between two groups . With the use of antibiotics ,the level of PCT decreased gradually .Conclusion Detecting and dynamic monitoring of PCT to guide anti-microbial selection and judgment the chang of patients? infectious state has important clinical significance .