Objective It is to observe the clinical effect of Qiangxin mixture on Hemodynamics and plasma NT - pro - BNP in patients with pre - clinical heart failure. Methods 60 cases of patients with pre - clinical heart failure were randomly divided into Qiangxin mixture treatment group (treatment group ) and basic western medicine treatment group ( control group ). The clinical curative effect, and the changes of ejection fraction , plasma NT - pro - BNP level and noninvasive hemodynamic monitoring indexes were observed in both groups . Results After treatment, the integral of the symptoms of renal asthenia in treatment group was obviously lower than that in control group . However, cardiac output, stroke volume, ejection fraction were significantly higher than that in control group , thoracic liquid content, systemic vascular resistance and plasma NT - pro - BNP lever were lower than that of control group. Conclusion Qiangxin mixture can inhibit the generation and progress of left ven -tricular remodeling by enhancing cardiac contraction , improving hemodynamics (increasing cardiac output and ejection frac - tion) and regulating the neuroendocrine factors (lowering the level of plasma NT - pro - BNP) , so that it could postpone the processes of heart failure.%目的 观察强心合剂对前临床心力衰竭患者血流动力学及血浆N-末端脑钠肽前体(NT-pro-BNP)水平的影响.方法 60例前临床心力衰竭患者随机分为西药基础治疗组(对照组)和强心合剂治疗组(治疗组),观察2组临床疗效、射血分数、血浆NT-pro-BNP水平和无创血流动力学指标的变化.结果 治疗后治疗组肾虚症状积分明显低于对照组,心排血量、每搏量、射血分数显著高于对照组,胸部液体含量、外周血管阻力、血浆NT-pro-BNP水平显著低于对照组.结论 强心合剂可能通过加强前临床心力衰竭患者心脏的收缩功能、改善血流动力学(增加心排血量,提高射血分数)及调节神经体液因子(降低血浆NT-pro-BNP浓度),干预心室重构发生、发展,从而延缓心力衰竭的进程.
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