目的：探讨艰难梭菌毒素A／B检测在台山地区院外和院内感染中的应用。方法收集2013年5月～2014年10月528例刚入院腹泻患者的粪便标本作为院外感染可疑病例组（院外感染组），年龄段在8～75岁，男249例，女279例；收集同时间段523例住院超一周以上并使用抗生素3天以上的患者的粪便标本作为院内感染的可疑病例组（院内感染组），年龄段在7～74岁，男209例，女314例。分别进行艰难梭菌毒素A／B检测，并结合细菌培养结果、临床诊断和疗效进行综合统计学分析。结果院外感染艰难梭菌率4％，院内使用抗生素后感染率16％。艰难梭菌毒素A／B检测对院外感染的检出率为85％，对院内感染的检出率为90％。结论艰难梭菌毒素A／B检测对台山地区院外和院内感染检测快速准确，值得在临床上推广应用。%Objective To investigate the application of Clostridium difficile toxin A/B detection on the out-side hospital and nosocomial infection in Taishan area .Methods The stool samples of 528 diarrhea patients newly admitted from May 2013 to October 2014 were collected as the outside hospital suspicious group , and the patients were aged 8 to 75 years old, including 249 males and 279 females.Relatively, the stool samples of 523 patients hos-pitalized more than a week and treated with antibiotics more than 3 days were collected as the nosocomial suspicious group, and the patients aged 7 to 74 years, 209 males and 314 females.Clostridium difficile toxin A/B was detected, and the comprehensive statistical analysis combined with thebacterial culture results , clinical diagnosis and curative effect was made .Results The clostridium difficile infection rate outside the hospital was 4% and the infection rate in hospital after using antibiotics was 16%.By Clostridium difficile toxin A/B detection , the positive rate of outside hospital infection was 85%, and that of nosocomial infection was 90%.Conclusion The Clostridium difficile toxin A/B detection is worthy of clinical application for its rapid and accurate outside hospital and nosocomial infection de -tection in Taishan area .
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