84例胆脂瘤型中耳炎致病菌的构成与其耐药性分析

摘要

Objective To study the distribution of chronic otitis media with cholesteatoma of mul-tidrug￣resistant bacteria and their sensitivity to antibiotics, to guide clinical rational drug use, im-prove the clinical efficacy. Methods From 2004 January to 2014 January in our hospital, 84 cases of chronic otitis media with cholesteatoma ear pus specimens for bacterial culture, and the strain was detected for drug sensitivity test, analyzed the correlation of drug sensitivity and resis-tance. Results All patients with cholesteatoma otitis media pathogensdistribution mainly were staphylococcus aureus. staphylococcus aureus, pseudomonas aeruginosa and pseudomonas aerugi-nosa; Sensitive rate of vancomycin in gram positive bacteria is much higher than that of other drugs, and gram negative bacteria in the highest sensitivity to imipenem, difference with statistical significance between two groups (P<0.05). Conclusion Thepathogenic bacteria of chronic otitis media with cholesteatoma kinds, clinicaltreatment should be carried out antibiotic drug sensitivity test, in order to avoid the overuse of antibiotics, increase the effect of antibiotic treatment.%目的：研究胆脂瘤型中耳炎多重耐药菌的分布与其对抗生素的敏感性，以指导临床合理用药，提高临床疗效。方法选取2004年1月～2014年1月于我院就诊的84例胆脂瘤型中耳炎患者的耳部脓液标本进行细菌培养，并对其菌株经行药物敏感性试验检测，分析其相关药物的敏感性和耐药性。结果所有胆脂瘤型中耳炎患者的致病菌分布主要依次为金黄色葡萄球菌、表皮葡萄球菌、铜绿假单胞菌及绿脓杆菌；革兰氏阳性菌对万古霉素的敏感率远高于其他药物，而革兰氏阴性菌中敏感率最高的为亚胺培南，组间比较差异具有统计学意义（P＜0.05）。结论胆脂瘤型中耳炎的致病菌种类繁多，临床治疗应进行抗菌素药物敏感性实验，以避免抗生素滥用，增加抗生素治疗的效果。