内皮祖细胞在急慢性肺损伤治疗中的研究进展

摘要

Endothelial progenitor cells ( EPCs ) are a specficc subtype of hematopoietic stem cells that have the propensity to differentiate into mature endothelial cells.Resent studies showed circulating endothelial progenitor cells played an important role in lung wound healing.Besides restoring pulmonary endothelialfunction, preserving integrity of the alveolocapillary barrier and suppressing the lung inflammatory response,EPCs can reverse endothelial dysfunction,inhibited puhnonary vessel remodeling, reduced puhnonary arterial pressure in healing of lung injury.Great progresses in acute lung injury and chronic pulmonary arterial hypertension with EPCs transplanting have been achieved.%内皮祖细胞(EPCs)是一种特殊表型的造血干细胞,它可以分化为成熟内皮细胞.近年来研究表明,EPCs肺组织损伤修复过程中有着重要作用.除了具有保护肺泡毛细血管屏障完整,减轻炎性反应,减轻肺组织损伤的作用外,EPCs还具有替代紊乱的肺血管内皮,防止肺血管重构,降低肺动脉压力的能力.目前EPCs移植在治疗急性肺损伤、慢性肺动脉高压方面的研究也取得了一定进展.