microRNAs与心力衰竭的研究进展

摘要

Heart failure is the main cause of rising mortality rate and the final phase of most of cardiovascular diseases. And at present all treatments are limited with incomplete curative effect. The latest sutdies show that microRNAs play an important role in the heart's physiological and pathological process,which can promote abnormal proliferation of the cardiomyocyte cell, and cause cardiomyocyte remodeling and myocardial hypertrophy, finally leading to heart failure. microRNA, which has the biological potential to negatively regulate gene expression,is a class of endogenous, non-coding small RNA. So the gene level therapy which inhibits the target gene and alter the expression of microRNAs may become a great breakgrough in the treatment of heart failure.%心力衰竭是大多数心血管疾病的最终归宿和导致病死率上升的主要原因,目前的治疗方法均有局限性,而且不能达到根治的目的.新近研究发现microRNAs(miRNAs)参与心脏的生理和病理过程,而且发挥重要的作用:促进心肌细胞异常增生参与心室重构进程和心肌肥厚,最终导致心力衰竭.miRNAs是一类内源性、非编码的小RNA,具有负性调节基因表达的生物学功能.从基因水平(miRNAs)治疗心力衰竭,即抑制miRNAs的靶基因和改变miRNAs表达等方法是一重大的突破口.