脓毒性休克是由感染所致的血流动力学的异常,是目前病死率较高的一种综合征.长期以来人们都将多巴胺作为治疗脓毒性休克的一线药物,而由于传统观点认为去甲肾上腺素具有减少肾脏及胃肠道黏膜的血流灌注等不良作用,认为去甲肾上腺素的应用是感染性休克预后不良的标志.然而,近来发现,去甲肾上腺素应用于脓毒性休克,不仅具有更好的有效率,而且其对于肾脏、胃肠道、心血管系统、呼吸系统及机体免疫系统的不良影响并不比多巴胺大.%Sepsis shock is a kind of abnormal hemodynamics caused by infection,which is a syndrome with high mortality. The guideline of sepsis shock indicates we can use vasoactive agents to keep patients' mean arterial pressure. For a long time,dopamine was the first choice for sepsis shock. The traditional views considered norepinephrine could reduce perfusion of kidney and gastrointestinal tract, and the using of norepinephrine was usually considered as bad prognosis. Recently, some researches indicated, for sepsis shock, norepinephrine could have better effect and less side-effect on kidney, gastrointestinal tract, cardiovascular system, respiratory system and immune system,which is a challenge to traditional views.
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