Norepinephrine Alone versus Norepinephrine Pluslow-Dose Dopamine: Enhanced Renal Blood Flow with Combination Pressor Therapy

摘要

Six normotensive, anesthetized dogs were infused intravenously with short-term, incremental infusions of norepinephrine (NE) with or without the addition of iv dopamine (DA) (4 micrograms/kg per min). The infusion of NE alone and in combination with low-dose DA produced similar, significant increases in mean arterial pressure. During the infusion of pressor doses of NE, the addition of DA resulted iln significantly higher renal blood flow (p < .001) and lower renal vascular resistance (p < .001) than infusions of NE alone. Thus, the renal vasodialating action of low-dose DA persisted despite infusions of NE, a potent vasopressor which decreases renal blood flow. This suggests that shock patients receiving therapy with NE should be good candidates to receive low-dose DA to enhance renal blood flow.