卡马西平诱发药疹与HLA-B在汉族人群中的关系

摘要

Stevens-Johnson综合征(SJS)和中毒性表皮坏死松解症(TEN)是一类发病率低却可危及生命的皮肤不良反应,卡马西平(CBZ)是常见诱发药物之一.近年来许多地区报道HLA-B*1502与CBZ在汉族人群中诱发SJS和TEN强相关,而在高加索人种中却没有类似发现,存在种族差异.目前CBZ仍然是临床中常用药物.现对CBZ诱发SJS和TEN与HLA-B*1502在汉族人群的关系进行综述,为临床用药安全性提供参考.%Stevens-Johnson syndrome( SJS ) and toxic epidermal necrolysis( TEN ) are rare but lifethreatening severe cutaneou adverse reactions. One of the drugs most frequently associated with SJS/TEN is cabamazepine. Recently, strong association between HLA-B * 1502 and carbamazepine-indeced SJS and TEN have been found in Chinese Han population,but not in Caucasian. Ethinicity might he a risk factor.Carbamazepine is prescribed in clinical work currently , the ohjective of this study is to review accociation HLA-B * 1502 with carbamazepine-indeced SJS/TEN in Chinese Han population and provide reference for drug safety.