TB has been a difficult problem of hazards to human health. With the use of Chemotherapy drags in the 1990s,the TB s rare rate of could be more than 95 % , so that we saw the the rare of the disease, and for a time we thought tuberculosiscould be controlled. However,the current situation is not that optimistic,even in some parts of the world, the TB crisis. Now, mycobacterium tuberculosis to first-line oral anti-TB dnis resistance is becoming increasingly serious, so that the chemotherapy have reduced efficiency. In this context,the authors proceed from reality , objective, scientific point of view, contained the resistance of tuberculosis, the mechanisms of resistance and the new progress of the rapid detection technologies.%结核病一直是危害人类健康的一个难题,20世纪90年代化疗药物的出现使结核病的治愈率达到95%以上,并一度认为结核病是可以控制并在全球消失的.然而,结核病的近况并不容乐观,甚至在全球部分地区出现了结核危机,尤其是结核分枝杆菌对一线口服抗结核药的耐药问题日益严重,致化疗的有效率下降.现就目前结核菌的耐药情况,一线口服抗结核药物的耐药机制及关于耐药结核菌快速检测方法、技术的新进展予以综述.
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