甲状腺功能亢进症与凝血功能

摘要

甲状腺疾病患者可发生凝血参数异常和临床凝血功能紊乱,甚至出现血栓或出血.与甲状腺功能亢进症(甲亢)有关的大多数凝血异常是甲状腺激素对各种凝血参数直接作用的结果,自身免疫因素也影响甲亢凝血过程.甲亢患者升高的甲状腺激素水平可影响凝血因子合成和作用、血管内皮细胞分泌、血小板成熟和功能等,从而导致凝血状态改变并有发生血栓形成的倾向.因此,应评估甲亢患者的凝血状态.%Thyroid disorders may rause abnormal coagulation parameters and rliniral coagulation disorders , even thrombsis or bleeding. Most oi the hemostatir all normalities associated with hypeithyioidism are the consequences oi direct effects oi thyroid hormones on various hemostatir parameters. Thyroid autoimmunity also aiiects the procession oi coagulation. Excess oi thyroid hormone can aiiect the synthesis and junction oi coagulation factors,vascular endothelial cells secretion,maturation and the junction oi platelets,which result in changes oi coagulation status in patients with hyperthyroidism and may result in thrombsis. Therefore,coagulation status oi patients with hyperthyroidism should be assessed.