炎症性肠病相关肝胆疾病的机制探讨

摘要

Inflammatory bowel disease( IBD) is a kind of chronic and nonspecific intestinal inflammatory disease with unclear etiology and pathogenesis.In addition to intestinal diseases,IBD can be complicated by multiple organs and systems,among which hepatobiliary complication is very common as an extraintestinal manifestations,with an important effect on the mortality of IBD.Hepatobiliary diseases mainly include primary sclerosing cholangitis(PSC),small biliary PSC,IgG4 associated cholangitis(IAC),non-alcoholic fatty liver, gallstones,primary biliary cirrhosis ( PBC ) etc.Most scholars believe that the IBD related liver disease is caused by environmental factors,microbial factors,immune factors and genetic susceptibility of the popula-tion,all of which result in abnormal immune response.%炎症性肠病（ IBD）是一种病因及发病机制未明，以慢性非特异性肠道炎症为主要表现的疾病。除肠道病变外，还可伴多器官、多系统受累，其中肝胆并发症是常见的肠外表现，对 IBD的病死率具有重要影响。肝胆疾病主要包括原发性硬化性胆管炎（ PSC）、小胆管性PSC、免疫球蛋白（ Ig） G4相关性胆管炎（IAC）、非酒精性脂肪肝、胆石症、原发性胆汁性肝硬化（PBC）等。 IBD相关肝胆疾病是由环境因素、微生物因素及免疫因素综合作用于遗传易患人群，引起异常免疫反应所致。