n－3多不饱和脂肪酸与血脑屏障的关系

摘要

The application of n-3 polyunsaturated fatty acid ( n-3 PUFA) in the central nervous system diseases is attracting more and more attention .Studies discover that the beneficial effects of n-3 PUFA on central nervous system diseases are related to the improvement of blood-brain barrier function.n-3 PUFA can be transported across the bloodb-rain barrier in several ways,and affect its permeability by modulating various related proteins through anti-inflammatory and antioxidant mechanisms .Although it has been proved that in animal models of several nervous system diseases that n -3 PUFA can protect the blood-brain barrier function and thus improve outcomes,clinical evidences are insufficient and more clinical studies are needed .%n－3多不饱和脂肪酸（ PUFA）在中枢神经系统疾病中的应用日益受到关注。研究发现，n－3 PUFA对神经系统疾病的作用与改善血脑屏障功能有关。 n－3 PUFA以多种方式透过血脑屏障，并通过抗炎、抗氧化等机制调节多种相关蛋白，从而对血脑屏障的通透性造成影响。虽然在多种神经疾病的动物模型中已经证实n－3 PUFA能起到保护血脑屏障并改善预后的积极作用，但临床证据尚不充分，还需要更多的临床研究来验证。