胰癌患者癌组织的中期因子和血管内皮生长因子的表达及临床意义

摘要

Objective: To investigate expression and clinical significance of midkine and vascular endothelial growth factor-C (VEGF-C) in pancreatic tumor tissue. Methods: Immunohistochemical S-P method was used to detect MK and VEGF-C in the pan-creatic tumor tissues. Results: The positive rates of VEGF-C and MK in the pancreatic tumor tissue were higher than those of adjacent tissue of carcinoma and chronic pancreatitis tissue (P<0. 05), and the difference between the adjacent tissue of carcinoma and chronic pancreatitis tissue was not significant (P>0. 05). Conclusions: MK and VEGF-C are important indicators in the early diagnosis and judgment of occurrence, development and metastasis of pancreatic cancer.%目的：：探讨胰癌患者的癌组织的中期胰腺肿瘤组织因子(MK)和血管内皮生长因子-C(VEGF-C)的表达及意义。方法：免疫组织化学 S-P 法检测胰癌患者的癌肿瘤组织内 MK、VEGF-C。结果：胰癌患者癌组织的 MK、VEGF-C 阳性率均高于癌旁组织和慢性胰腺炎患者的胰组织(P<0.05)，胰癌患者癌旁组织与慢性胰腺炎患者的胰组织对比(P>0.05)。胰癌患者癌组织的 MK 阳性率及 VEGF-C 阳性率均高于癌旁组织和慢性胰腺炎患者的胰组织(P<0.05)；癌旁组织及慢性胰腺炎患者的胰组织的 MK 阳性率及 VEGF-C 阳性率对比，无差异(P>0.05)。结论：MK、VEGF-C 是胰癌早期诊断、发展和转移的重要指标。