药物自我处置及药物自我监控对首发精神分裂症患者复发的影响

摘要

Objective:To explore effects of drug self-disposal and symptom self-monitoringpattern on recurrence of patients with first-episode schizophrenia(FEP). Methods:120cured first-episode schizophrenia patients were randomly divided into the train-ing group (n=60) and control group (n=60). Both groups received atypical antipsychotics, but the training group was given the drug self-disposal and symptom self-monitoring training for 8 weeks, additionally. All subjects were evaluated with positive and negative symptoms scale(PANSS) and social disability screening schedule(SDSS) at 2, 4, and 8-week as well as 1-year follow-up. Results:(1)At the end of the follow-up,the recurrence rate of the training group was lower than the control group(P<0. 01). (2) The PANSS score of the training group was significantly lower than the control group from 4 weeks after the training(P<0. 05). (3) The SDSS score of the training group was significantly lower than the control group from 4 weeks after the training(P<0. 01). Conclusions:Drug self-disposal andsymptom self-monitoring pattern has a positive effect on control ling mental symptoms, preventing recurrence,and im-proving social function.%目的：：探讨药物自我处置及症状自我监控对首发精神分裂症( FEP)患者复发的影响。方法：选取经治疗达临床痊愈的FEP患者120例，随机分成训练组和对照组，每组各60例。对照组患者单纯给予药物治疗；训练组患者在对照组的基础上接受药物自我处置和症状自我监控训练8周。并于训练第2周末、4周末、8周末及随访1年末评定PANSS、SDSS。结果：①随访结束时，训练组患者复发率明显低于对照组，有显著性差异(P<0.01)；②训练4周末起开始，训练组患者的PANSS总分低于对照组，差异有统计学意义(P<0.05)；③训练4周末起开始训练组SDSS评分显著低于对照组(P<0.01)。结论：药物自我处置和症状自我监控训练，对控制FEP患者精神症状、预防复发、改善社会功能有积极作用。