pH-sensitivity gelatin-pectin and chitosan-octyl-pectin hydrogels based on gelatin and pectin were synthesized by using glutaraldehyde as crosslink agent. The effects of the degree of the dosage of crosslinking, temperature and pH on the swelling behaviors of the hydrogels and swelling-deswelling properties were also studied. Results show that when the temperature is at the range of 30~60℃ , swelling rate of hydrogels increased with temperature increasing and manifested "thermal expansion-type" hydrogels. The swelling rate of hydrogels with pH-sensitivity were larger in alkaline conditions than that of in acidic conditions. Swelling-deswelling kinetics of hydrogels in different pH conditions showed that the gelatin-pectin hydrogels have "shape memory" function. The release behavior of bovine serum alumm embedded in the hydrogels was of distinctly difference with the changes of pH value of loading medium. The release of bovine serum alumin in those two kinds of hydrogels in the medium of pH= 1. 0 was much quicker than in pH=7, 8 and pH = 9. 18. These gels might be useful for pH and temperature controlled release of proteins.%以戊二醛为交联剂,制备了pH敏感性明胶-果胶水凝胶(GT-PT)和明胶-辛基果胶水凝胶(GT-OPT),研究了交联剂用量、温度、pH值对凝胶溶胀性能的影响及溶胀-消溶胀性能.结果表明,当温度在30～60℃时,凝胶的溶胀率随温度的升高而增大；且具有明显的pH敏感性,碱性条件下的溶胀率大于酸性条件下的溶胀率；不同pH值条件下,明胶-果胶水凝胶具有“形状记忆”功能.包埋在水凝胶中的牛血清蛋白在pH=1.0时的释药率大于pH=7.8和pH=9.18时的释药率.此类水凝胶有望用于蛋白质的pH值及温度控制释放.
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