PVA/P(AA-AM)IPN hydrogel was synthesized by water solution polymerization with polyvinyl alcohol(PVA),acrylic acid(AA)and acrylamide(AM)as the monomers and(NH4)2S2O8,BIS as the initiator and crosslinker,respectively. The hydrogel was characterized by TG/DSC,FTIR spectrum and SEM. The swelling properties,the effects of ionic strength,monomer content in PVA/P( AA-AM) hydrogels and pH values on the swelling ratio were also investigated. In addition,the characteristic for drug deliv-ery was studied using Isonicotinyl hydrazide( INH) and nicotinic acid as the model drug in different pH buffer solutions with. The re-sults showed that PVA/P( AA-AM) hydrogels had good sensitivity for pH values and ionic strength. The cumulative release amounts of INH are higher than that of VB3 both in pH=6. 86 and pH=1. 80 media. However,the cumulative release amounts of INH is higher and the release rate is quicker in pH=1. 80 solution than which in pH=6. 86 solution. The results of VB3 are different com-pletely from INH. Therefore the prepared hydrogel is expected to be used as the carrier of drug release.%以聚乙烯醇( PVA)、丙烯酸( AA)和丙烯酰胺( AM)为单体,过硫酸铵( APS)为引发剂、N,N′-亚甲基双丙烯酰胺(MBA)为交联剂,通过化学引发聚合制备互穿水凝胶PVA/P(AA-AM)；用红外光谱(IR)、热重分析( TG)、差示扫描量热法( DSC)及扫描电镜( SEM)等测试方法对其进行了表征,并对其溶胀性能、pH敏感性以及离子强度对溶胀性能的影响进行了研究；并考察了该凝胶分别在pH=6．86和pH=1．80介质中对药物异烟肼和烟酸的控制释放行为。结果表明,PVA/P( AA-AM)水凝胶具有良好的pH、离子强度敏感性,在两种介质中异烟肼的累积释放率均高于烟酸,但异烟肼在pH=1．80的介质中的释放速度和累积释放率均高于其在pH=6．86的介质,烟酸则结果恰好相反。所以这种水凝胶有望用作靶向药物释放的载体。
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