利用真空热还原法制备得到氧化锡粒子/石墨烯纳米复合材料(SnO2/GR)，该过程中，石墨烯氧化物原料既是氧化锡粒子的有效载体来源，也是新型的活泼氧给体，可同步将零价锡氧化为正四价锡，石墨烯氧化物原料则被还原为石墨烯。利用透射电镜(TEM)、扫描电镜(SEM)、X 射线衍射(XRD)和傅里叶变换红外光谱等分别对氧化锡粒子/石墨烯纳米复合材料的形貌和尺寸、结构进行了表征。利用该新型材料在近红外(NIR)激光照射下的强光热转化性能，使相比健康细胞更易受到温度影响的胰腺肿瘤细胞内部产生过高热(Hyperthermia)，从而诱导胰腺肿瘤细胞热损伤及细胞凋亡。实验结果表明，在1064 nm 近红外激光照射下，对照组胰腺肿瘤细胞仍保持较高活性，而实验组的胰腺肿瘤细胞活力则大幅降至5.03%，充分显示了氧化锡粒子/石墨烯纳米复合材料在胰腺肿瘤热疗领域的潜力。%Tin (Ⅳ)oxide nanoparticles/graphene (SnO2/GR)nanocomposites were prepared via vacuum ther-mo treatment of Tin (0)and graphene oxide (GO).A redox reaction would occur readily in this process,in which the novel oxygen donor:GO could act as the oxidizing agent to oxidize Tin (0)to Tin (Ⅳ),meanwhile,the graphene pre-cursor:GO would be simultaneously reduced to graphene by Tin (0)readily.The resulted composites were characte-rized by Fourier transform infrared spectrometry,scanning electron microscopy,and X-ray diffraction spectroscopy etc..The novel SnO2/GR nanocomposites could combine both advantages of inorganic metal nanoparticles and gra-phene for near infrared spectroscopy (NIR)light absorption to generate heat,which fosters SnO2/GR a special candi-date for photothermal ablation therapy (PTA)with NIR.Further investigations showed that the SnO2/GR nanocom-posites with NIR features could provide viable option for enhancing the thermal deposition (as it could significantly re-duce the survival rate of cancer cell to 5.03% with the presence of a 1064 nm NIR)and specificity of hyperthermia treatments for elimination of human prostate cancer (PC3).
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