成人部分性癫痫患者的睡眠结构与听觉事件相关电位的特征及相关性研究

摘要

目的：探讨成人部分性癫痫患者的睡眠结构与听觉事件相关电位（AERPS）的特征及相关性。方法选取2012年5月至2014年8月本院收治的54例成人部分性癫痫患者作为研究组，另选取54例同期健康体检者作为对照组，均行 AERPS 和睡眠脑电图监测，分析两组对象睡眠参数和 AERPS 参数，并探讨其相关性。结果研究组总睡眠时间、睡眠效率和非快速眼动睡眠（NREM3）＋4期占总睡眠时间百分比较对照组低，而 NREM1期、NREM2期和清醒期占总睡眠时间百分比较对照组高，差异均有统计学意义（P＜0．05）。研究组潜伏期 P300高于对照组，差异有统计学意义（ P ＜0．05）。研究组患者 P300潜伏期与 NREM3＋4期占总睡眠时间百分比（r＝-0．452，P＜0．05）、睡眠效率（r＝-0．413，P＜0．05）呈负相关，与其余睡眠参数间无明显相关性。结论成人部分性癫痫患者睡眠结构和 AERPS 均发生异常，其中睡眠参数的变化与 P300潜伏期有负相关性。%Objective To investigate the characteristics and correlation of sleep architecture and auditory e-vent-related potentials (AERPS) in adult patients with partial epilepsy .Methods A total of 54 cases of adult partial epilepsy I our hospital from May 2012 to August 2014 were chosen as the research group and contemporaneous 54 in-dividuals undergoing the healthy physical examination were chosen as the control group .The sleep EEG and AERPS monitoring was performed in the two groups .The sleep parameters and AERPS parameters in the two group were analyzed and their relationship was investigated .Results The total sleep time ,sleep efficiency and the percentages of NREM3 + 4 accounting for total sleep time in the research group were lower than those in the control group ,while the percentages of NREM1 ,NREM2 and wakefulness accounting for the total sleep time were higher than those in the control group ,the differences were statistically significant (P< 0 .05) .The research group had a significant longer P300 latency than the control group with statistical difference(P< 0 .05) .The P300 latency in the research group had negative correlation with the percentage of NREM3 + 4 accounting for the total sleep time(r = - 0 .452 ,P < 0 .05) and sleep efficiency(r= - 0 .413 ,P< 0 .05) ,while had no significant correlation with other sleep parameter .Conclu-sion The sleep architecture and AERPS in adult patients with partial epilepsy are all abnormal ,in which the sleep parameter change has negative relationship with P300 latency .