目的 探讨急性脑梗死(ACI)患者血清白细胞介素-6(IL-6)、白细胞介素-8(IL-8)和肿瘤坏死因子-α(TNF-α)的水平变化及临床意义.方法 ACI组85例患者分为轻度组31例,中度组29例和重度组25例；另选择同期进行健康体检者40例作为对照组；采用酶联免疫吸附法测定血清IL-6、IL-8和TNF-α水平.结果 ACI组患者血清IL-6、IL-8和TNF-α水平显著高于对照组(P＜0.05),重度组患者血清IL-6、IL-8和TNF-α水平显著高于轻度组和中度组(P＜0.05),中度组患者血清IL-6、IL-8和TNF-α水平显著高于轻度组(P＜0.05).结论 血清IL-6、IL-8和TNF-α水平升高可能与ACI的发生和发展有关,检测血清IL-6、IL-8和TNF-α水平有助于评估ACI患者的病情及预后.%Objective To explore the change and clinical significance of the levels of serum interleukin-6 (IL-6), interleukin-8 (IL-8 ) and tumor necrosis factor-a(TNF-ot) in patients with acute cerebral infarction ( ACI). Methods Eighty-five patients with ACI of ACI group were divided into the mild group ( n = 31) , moderate group (n = 29) and severe group (n = 25); at the same time, forty healthy people were chose as control group. The levels of serum IL-6, IL-8 and TNF-α were detected with enzyme linked immunosorbent assay. Results The levels of serum IL-6, IL-8 and TNF-a in ACI group were significantly higher than those in control group(P<0. 05). The levels of serum IL-6,IL-8 and TNF-a in severe group were significantly higher than those in mild group and moderate group ( P < 0.05). The levels of serum IL-6, IL-8 and TNF-a in moderate group were significantly higher than those in mild group(P <0. 05). Conclusion Serum IL-6,IL-8 and TNF-a levels increasing may be related with the occurrence and development of ACI. The detection of serum IL-6,IL-8 and TNF-a should be helpful to assess the severity and prognosis of patients with ACI.
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