新疆喀什维吾尔族人群血清25羟维生素D及血钙与血压的相关性

摘要

目的探讨维吾尔族受检人群的血清25羟维生素D[25（OH）D]及血钙水平与血压的关系。方法采用分层随机抽样的方法于2012年12月-2013年1月在新疆喀什地区纳入维吾尔族受检者共232例，其中原发性高血压患者132例（高血压组），正常对照者100例（正常对照组）。检测其血压、血清25-羟维生素D和血钙、磷相关指标，分析血清25（OH）D及血钙水平对血压的影响。结果维吾尔族原发性高血压患者血清25（OH）D、血钙水平低于维吾尔族正常对照组，体质指数高于维吾尔族正常对照组，差异有统计学意义；维生素D缺乏组患者收缩压高于维生素D不足组；血钙低于维生素D不足组，差异均有统计学意义；血清25（OH）D每下降6 ng/mL ，收缩压升高的危险性增加0．68；体质指数每增加5 kg/m2，血压升高的危险性增加1．78；血钙每增加0．2 mmol/L ，舒张压≥90 mmHg的危险性降低0．42。结论新疆维吾尔族受检人群普遍存在维生素D缺乏，高血压患者维生素D水平更低；维吾尔族血清25（OH）D水平、体质指数对血压有一定的影响，血钙水平对舒张压有一定的影响。%Objective To explore the relationship between 25-hydroxy-vitamin D levels calcium and blood pressure in Uygur population ,by study the level of serum 25(OH)D and calcium phosphorus metabolism related indicators .Methods To investigate in Xinjiang Kashgar region from December 2012 to January 2013 .Using stratified random sampling method .All the 232 subjects including 132 cases of essential hy-pertension and 100 cases with normal .The detection of blood pressure and 25-hydroxy-vitamin D levels and relevant indicators of calcium and phosphorus ,analyse the relationship between serum 25(OH)D level and calcium and blood pressure .Results The level of serum 25(OH)D levels ,serum calcium in essential hypertension group were lower than the normal group ,the level of body mass index was higher than nor-mal group;Admission every 6 ng/mL descend in 25(OH)D ,risk of elevated systolic blood pressure in-creased to 0 .68 ;T he level of body mass index increased 5 kg/m2 ,the risk of elevation of blood pressure increased to 1 .78 ;Calcium increased 0 .2 mmol/L ,the risk of diastolic blood pressure≥90 mmHg reduced Objective To explore the relationship between 25-hydroxy-vitamin D levels calcium and blood pressure in Uygur population ,by study the level of serum 25(OH)D and calcium phosphorus metabolism related indicators .Methods To investigate in Xinjiang Kashgar region from December 2012 to January 2013 .Using stratified random sampling method .All the 232 subjects including 132 cases of essential hy-pertension and 100 cases with normal .The detection of blood pressure and 25-hydroxy-vitamin D levels and relevant indicators of calcium and phosphorus ,analyse the relationship between serum 25(OH)D level and calcium and blood pressure .Results The level of serum 25(OH)D levels ,serum calcium in essential hypertension group were lower than the normal group ,the level of body mass index was higher than nor-mal group;Admission every 6 ng/mL descend in 25(OH)D ,risk of elevated systolic blood pressure in-creased to 0 .68 ;T he level of body mass index increased 5 kg/m2 ,the risk of elevation of blood pressure increased to 1 .78 ;Calcium increased 0 .2 mmol/L ,the risk of diastolic blood pressure≥90 mmHg reduced to 0 .42 .Conclusion The trained people of Xinjiang Uygur nationality have high morbidity of Vitamin D deficiency ,essential hypertension patients are more seriously suffered from Vitamin D deficiency than normal ;The Uighurs serum 25(OH)D levels and calcium levels and blood pressure there is a certain relationship .