The serum level of 25-hyroxyvitamin D and the hepatic necroinflamatory activity in hepatitis C virus infection

摘要

Low levels of serum 25-hyroxyvitamin D (25(OH)D) related to severe fibrosis have been recently reported in hepatitis C virus (HCV) infection. The objective of our study was to assess the plasma levels of 25(OH)D in HCV infection and its correlation with the immune status and necroinflamatory activity. The level of serum calcium (Ca), phosphorus (Ph), 25(OH)D, alanine aminotransferase , aspartate aminotransferase, and the count of CD4+T cells and CD8+T cells were measured in 25 patients with HCV infection and 21 controls and correlated with the Actitest/Fibrotest results. All the HCV patients and healthy controls displayed a significantly lower plasma level of 25(OH)D (29.5714 nmol/1, respectively 29.2701 nmol/1). Despite the critically low 25(OH)D concentration, the phosphocalcium serum values were in the normal range. The patients with a high necroinflamation score (A2-A3) displayed a strong positive correlation between 25(OH)D and ALT plasma levels (R=0.530) as well as between the 25(OH)D and the CD4+T cells number (R=0.703). In these patients, the CD4+T cells count was correlated not only with the 25(OH)D serum level but also with the serum calcium concentration (R=0.841). Patients with a lower inflammation score (A0-A1) presented a negative correlation between 25(OH)D and TGO (R= - 0.548). In conclusion, strong positive correlations were found between the 25(OH)D plasma levels, the immune status and calcium levels in patients with HCV and high necroinflammatory activity.