扶正消瘕方治疗胃癌前病变的临床疗效观察

摘要

Objective To observe the curative effect of Fuzhengxiaojia decoction on precancerous lesion of gastric cancer (PLGC).Methods We randomly divided 44 patients with PLGC in our hospital into control group (n=22)and treatment group (n=22).The control group was given 4 Weifuchun tablets each time and three times per day and while the treatment group was given one Fuzhengxiaojia decoction of 400 mL besides the medication of the control group.They were treated for two courses,one course lasting for one month.Results Superoxide dismutase (SOD),malondialdehyde (MDA),glutathione peroxidase (GSH-Px),IgG,IgM and IgA in the two groups had no significant differences before treatment (P＞0.05).After treatment,compared with those in the control group,SOD (t=2.144,P=0.044)and GSH-Px (t=2.322,P=0.030)increased,while MDA(t=3.096, P=0.005),IgG(t=2.421,P=0.025),IgM(t=3.377,P=0.003)and IgA (t=2.521,P=0.020)decreased. The main symptom scores in the two groups did not significantly differ before treatment (P＜0.05).After treatment, compared with those in the control group,the scores for main symptoms like reduced food intake (t=3.924,P＜0.001),stomach noise (t=4.161,P＜0.001)and gastric or hypochondriac swelling (t=2.881,P＜0.009) decreased in the treatment group.The rate of effective cases was higher than that in the control group (χ2=4.539, P=0.033).Conclusion The effect of Weifuchun combined with Fuzhengxiaojia prescriptions in treating PLGC is better than Weifuchun alone,which is related to improving redox and immunoglobulin.%目的 观察扶正消瘕方治疗胃癌前病变(precancerous lesion of gastric cancer,PLGC)的疗效.方法 选择我院PLGC患者44 例,随机分为对照组和治疗组.对照组给予胃复春片口服4 片/次,3 次/d;治疗组在对照组基础上加服扶正消瘕方加减每日 1 剂,水煎服400 mL.1 个月为 1 个疗程,连服 2 个疗程.结果 2 组治疗前的超氧化物歧化酶(superoxide dismutase,SOD)、丙二醛(malondialdehyde,MDA)、谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)、IgG、IgM和 IgA无统计学差异(P＞0.05).治疗后,与对照组相比,治疗组的 SOD(t=2.144,P=0.044)和GSH-Px(t=2.322,P=0.030)升高,MDA(t=3.096,P=0.005)、IgG(t=2.421,P=0.025)、IgM(t=3.377,P=0.003)和 IgA(t=2.521,P=0.020)降低.治疗前 2 组中医主要症状积分无统计学差异(P＞0.05);治疗后,与对照组相比,治疗组的中医主要症状饮食减少(t=3.924,P＜0.001)、胃中嘈杂(t=4.161,P＜0.001)和胃脘或胁肋胀(t=2.881,P＜0.009)积分降低,总有效率增高(χ2=4.539,P=0.033).结论 胃复春片联合扶正消瘕方加减治疗PLGC较单纯中成药治疗有更好的疗效,与改善氧化还原及免疫球蛋白有关.