血清标志物（NSE、CEA、CA-125、CYFRA21-1）和分子标志物（MDR-1、LRP、RRM-1、EGFR、ERCC-1、BRCA-1）在非小细胞肺癌患者原发灶和转移淋巴结的表达

摘要

AIM:To investigate the different expressions of ser-um markers and molecular markers in the primary tumor and the metastatic lymph nodes of lung cancer patients with four histologi-cal subtypes.METHODS:There were 48 cases of lung cancer patients who underwent thoracic surgery for removal of primary and metastatic lesions had been enrolled for testing.RESULTS:Expression of ERCC-1 was significantly different in primary tumors and metastatic sites (P=0.007 )and the serum level of CEA was significantly different for patients with different cancer subtypes (P =0.008 ). CONCLUSION:Tumor molecular markers have value to estimate prognosis and select treatments for patients.%目的：研究不同血清标志物及分子标志物在肺癌不同病理亚型、原发灶与转移淋巴结间表达的差异．方法：对48例住院接受开胸手术切除原发病灶及转移淋巴结的患者进行4种血清标志物和6种分子标记物检测．结果：ERCC-1的表达在原发肿瘤和转移部位间有显著差异（P＝0．007）；CEA的血清水平在不同肿瘤亚型患者间存在显著差异（P＝0．008）．结论：标志物检测对于患者预后的判断及治疗方案具有一定价值．