TMEM16A在胃腺癌中的表达及意义

摘要

Objective To investigate the expression of TMEM16A in gastric carcinoma and its clinical implications- Methods A total of 72 surgical specimens of gastric carcinoma were collected for examination of TMEM16A expression with immunohistochemical staining.Results TMEM16A expression was detected in the cytoplasm and cell membrane of the tumor cells.Of the 72 specimens of the tumor tissues,the total positivity rate of TMEM16A expression was 80-56% (58/72),significantly higher than the rate in the adjacent tissues (4.17%,3/72,P<0.005}.Conclusion Aberrant expression of TMEM16A occurs in the majority of gastric carcinoma cases.TMEM16A can be used as a new candidate target for diagnosis and treatment of gastric carcinoma.%目的 探讨Ca2+激活的氯离子通道(CaCC)蛋白TMEM16A在胃癌中的表达和意义.方法 收集72例胃癌标本,采用免疫组织化学SP法检测TMEM 16A的表达,以癌旁胃粘膜组织和非肿瘤胃粘膜组织作为对照,胃间质瘤组织作为阳性对照.结果 TMEM 16A表达于胃癌细胞胞膜和胞质内,在72例胃癌中TMEM 16A呈不同程度阳性表达,在胃癌组织中TMEM 16A表达的总阳性率(“阳性”和“强阳性”)为80.56％(58/72)；而在相应的癌旁组织中TMEM 16A表达的总阳性率(“阳性”和“强阳性”)仅为4.17％ (3/72),两者之间差异显著(P＜0.005).结论 TMEM16A高表达于胃癌组织,可作为胃癌的分子诊断和靶向治疗的一个新的候选靶点.